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For example, diseases of the urinary system can lead to house-soiling. Diseases of the endocrine organs such as the thyroid gland and pituitary gland can lead to a variety of behavioral and personality changes. A decline in the senses (hearing and sight) and the onset of painful conditions, and those that affect mobility may cause the pet to be more irritable or more fearful of approach and handling. Ageing pets may also develop a range of behavioral changes associated with senility which are similar to the changes seen in Alzheimer's disease in people. How can I tell if my pet's behavior problem is age related? Regardless of age, every behavior case must begin with a complete veterinary physical examination and a clinical and behavioral history. In addition, blood tests and a urinalysis may be needed to rule out organ disease and endocrine imbalances. Sometimes a more in depth examination of a particular organ system may be indicated. Additional laboratory tests, radiographs, ultrasound, spinal tests or brain scans may all be appropriate depending on the initial findings and most of these will involve referral to a specialist at a University or referral practice. My pet is quite old. Is there any point in doing these tests? What can be done? Unfortunately many owners of elderly pets do not even discuss behavior changes with their veterinary surgeon since they feel that they are a normal part of ageing and perhaps nothing can be done for their pet. This is far from the truth. Many problems have an underlying medical cause that can be treated or controlled with drugs, diet or perhaps surgery. Hormonal changes associated with an underactive or overactive thyroid gland, diabetes, diseases of the pituitary gland and testicular tumors can all lead to dramatic changes in the pet's behavior and many of these problems can be treated or controlled. Fading organ systems can often be aided with nutritional supplementation or dietary changes. High blood pressure, cardiac disease and respiratory diseases may be treatable with medication, which may dramatically improve the quality and even length of the pet's life and new drugs are now available that are useful in the treatment of age related behavioral changes associated with senility.
What is cognitive dysfunction and how is it diagnosed? It is generally believed that, as in people, a dog's learning ability, concentration, memory and mental alertness tends to decline with age and this decline is termed dysfunction. This may also be true for cats. If your dog has one or more of the following behavior changes and all potential physical or medical causes have been ruled out, it may be due to cognitive dysfunction: a) Decreased reaction to stimuli (i.e. sounds, sights, odors) b) Confusion, disorientation, weakness c) Decreased interaction with the owners (e.g. less affectionate) d) Increased irritability e) Irregular sleep-wake cycles (sleeping in the day, waking more at night) f) Increased vocalization g) House-soiling or loss of other previously learned behaviours h) Decreased ability to recognize commands, people, places or other animals i) Decreased interest in food j) Circling, repetitive and compulsive disorders k) Decreased tolerance to being left alone In one study of dogs that were 11-16 years of age, owners who were specifically questioned regarding signs of cognitive dysfunction reported that 62% of their pets exhibited at least one of the above signs. Do pets get Alzheimer's? Many of the same changes and lesions associated with Alzheimer's disease in people have also been recognized in dogs and cats. When multiple behavior problems develop and these changes progress to the point where the dog or cat is no longer a "functional" pet, the condition may be consistent with senility or dementia of the Alzheimer's type. Can geriatric behavior problems be treated? In many cases the answer is yes. Of course if there are medical problems contributing to the behavior changes, the problem may not be treatable. The key therefore is to report any behavioral changes in your pet and contact your veterinary surgeon as soon as new problems arise. In cognitive dysfunction, depletion of brain dopamine levels, may be responsible for many of the behavior changes. New drugs are available that can successfully treat some forms of cognitive dysfunction in dogs. Selegiline helps to normalize the brain dopamine levels, helps to protect against nerve cell deterioration and has few side effects. It is licensed for the treatment of behavioral problems of an emotional origin including those listed above which are related to old age. Nicergoline increases blood supply to the brain and also protects the brain cells from certain types of damage due to a lack of sufficient oxygen. It is licensed for the treatment of certain specific age-related effects in the older dog but may also be used to treat some behavioral problems in the older dog associated with senility e.g. loss of house-training. Many of the behavior problems listed above will show marked improvement and overall these dogs may become more attentive, playful and affectionate. It is important to note that retraining and changes to the environment may also be needed to resolve the problem. For example, in addition to drug therapy, geriatric dogs that have begun to eliminate indoors will also need to be retrained much like a puppy that has begun to eliminate indoors. Dogs that develop behavior problems due to underlying medical conditions may need alterations in their schedule or environment in order to deal with these problems.
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