PROSTATIC DISEASE
What is the prostate?
The prostate (commonly mispronounced as "prostrate") is a gland located near
the neck of the urinary bladder of male dogs. The urethra passes through it
shortly after leaving the bladder. The purpose of the prostate is to produce
some of the fluids found in normal canine semen.
What are the signs of prostatic disease?
Enlargement of the gland is common with most prostatic diseases. Since the
urethra passes through it, enlargement of the prostate compresses the urethra,
and urination becomes difficult. Complete urethral obstruction only rarely occurs,
but an affected dog will spend quite a bit of time urinating and produces a
stream of urine with a small diameter. The colon, located just above the prostate,
is sometimes compressed by an enlarged prostate. This makes defecation difficult.
In summary, a dog with prostatic enlargement often has a history of straining
to urinate and/or defecate. In addition, some dogs with prostatic disease will
have blood in the urine. Bacterial infection of the prostate is sometimes, but
not always, involved with production of the bloody urine.
What are the diseases that cause the prostate to enlarge?
There are at least seven diseases affecting the prostate.
1. Benign prostatic hyperplasia. This is a non-cancerous enlargement of the
gland. It is associated with the hormone testosterone and is the most common
disease of the prostate.
2. Squamous metaplasia. This is a non-cancerous enlargement of the gland
caused by excess amounts of estrogen. An estrogen-producing tumor called a Sertoli
cell tumor is usually responsible.
3. Cystic hyperplasia. This condition is usually secondary to benign prostatic
hyperplasia or squamous metaplasia. It is caused by obstruction of the ducts
that carry prostatic secretions to the urethra. Multiple, fluid-filled cavities
result.
4. Paraprostatic cysts. These are fluid-filled cysts that develop adjacent
to the prostate when abnormal tissue remains from embryonic development before
the puppy was born. The cysts begin to develop shortly after birth but may not
cause problems or be detected until the dog is several years old.
5. Bacterial infection. Bacteria may enter and infect the prostate by going
up the urethra or by coming down the urethra from an infection in the urinary
bladder. It is usually associated with a preexisting abnormality of the prostate,
such as benign prostatic hyperplasia.
6. Prostatic abscess. This is a progressive form of a bacterial infection.
If the ducts that drain the prostate become obstructed, bacteria are trapped
in the prostate and form an abscess which is really a 'walled-off' site of infection.
7. Prostatic cancer. This form is much less common than all of the others.
It may be associated with hormones from the testicles, adrenal glands, or pituitary
glands or it may occur without any association with hormones.
How are these diagnosed?
The first step in diagnosis is to determine if the prostate is enlarged. This
is done by feeling its size either through the abdominal wall or through the
rectal wall. It may be confirmed by radiographs (x-rays) or an ultrasound examination.
Because there are so many diseases of the prostate, it is necessary to perform
several tests to tell them apart. These tests include cultures of the dog's
urine, a microscopic examination of the cells in the urine, and a microscopic
examination of the cells in prostatic fluid or in the prostate itself. Samples
of prostatic fluid are recovered by passing a urethral catheter to the level
of the prostate and massaging the prostate to "milk" fluid out of it. Samples
of prostatic cells are obtained by aspiration or biopsy via a needle that is
either passed through the body wall or passed through the rectal wall. If the
prostate is greatly enlarged, it can be aspirated or biopsied through the body
wall; otherwise, an approach through the rectal wall is necessary. An aspiration
sample is taken through a very small bore needle and only recovers a few cells.
Sometimes this is adequate for analysis; other times it is not. A needle biopsy
sample is obtained through a large bore needle that is passed into the prostate
using radiography or ultrasound. A biopsy involves an operation which recovers
a piece of tissue that permits a pathologist to make a more accurate diagnosis.
How are they treated?
1. Diseases involving primary or secondary bacterial infections are treated
with aggressive antibiotic therapy. Because it is difficult to get many antibiotics
into the prostate, treatment for several weeks will probably be necessary. Since
most of the infections are secondary to another disease, treating the infection
is only part of the overall treatment.
2. Diseases associated with excessive hormone levels include benign prostatic
hyperplasia, cystic metaplasia, and cystic hyperplasia. Since testosterone and
estrogen are both formed in the testicles, castration is generally very effective
for all of these. The prostate will generally be normal or smaller than normal
in size within one month after castration.
3. Paraprostatic cysts and prostatic abscesses require major abdominal surgery
to drain and remove.
4. Prostatic cancer does not respond well to any currently used form of treatment.
If it is associated with an excess of a hormone, castration may be beneficial;
however, most are not and metastasize rather easily to other parts of the body.
The prognosis for these is usually poor.
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